| 1 | Emmaus High School | Emmaus, Pennsylvania | 22-0-0 | 1 | 10/28 vs Whitehall- 12-0 W | |
| 2 | Episcopal Academy | Newtown Square, Pennsylvania | 16-1-0 | 2 | 10/27 vs Springside Chestnut Hill Academy- 9-2 W, 10/29 vs Penn Charter- 10-0 W | |
| 3 | The Hill School | Pottstown, Pennsylvania | 15-1-0 | 3 | 10/27 vs Germantown Academy- 7-1 W, 10/30 vs Mercersburg Academy- 6-0 W | |
| 4 | Lower Dauphin High School | Hummelstown, Pennsylvania | 18-0-1 | 4 | 10/30 vs Dallastown- 2-1 W | |
| 5 | Villa Maria Academy | Malvern, Pennsylvania | 16-2-1 | 5 | 10/26 vs Harriton- 13-0 W, 10/28 vs Pope John Paul II- 10-0 W | |
| 6 | Wyoming Seminary | Kingston, Pennsylvania | 16-2-0 | 6 | 10/28 vs Tunkhannock- 12-0 W | |
| 7 | Palmyra Area High School | Palmyra, Pennsylvania | 16-1-1 | 7 | 10/27 vs West Perry- 3-1 W, 10/30 vs Hershey- 5-0 W | |
| 8 | Conestoga High School | Berwyn, Pennsylvania | 19-1-0 | 8 | 10/27 vs Downingtown East- 4-0 W, 10/29 vs Kennett- 3-0 W | |
| 9 | Gwynedd Mercy Academy High School | Gwynedd Valley, Pennsylvania | 14-2-1 | 9 | 10/26 vs Strath Haven- 14-0 W, 10/28 vs WC East- 5-0 W | |
| 10 | Twin Valley High School | Elverson, Pennsylvania | 21-2-0 | 10 | 10/27 vs Berks Catholic- 9-1 W, 10/30 vs Garden Spot- 5-0 W | |
| 11 | Wyoming Area High School | Exeter, Pennsylvania | 16-1-0 | 11 | None | |
| 12 | Oley Valley High School | Oley, Pennsylvania | 19-2-0 | 12 | 10/30 vs Susquehanna Twp- 2-0 W | |
| 13 | Academy of Notre Dame de Namur | Villanova, Pennsylvania | 13-4-0 | 13 | 10/26 vs William Penn Charter- 8-0 W, 10/28 vs Germantown Academy- 3-0 W | |
| 14 | Greenwood High School | Millerstown, Pennsylvania | 17-1-0 | 14 | 10/30 vs Littlestown- 6-0 W | |
| 15 | Wilson High School | West Lawn, Pennsylvania | 17-4-0 | 15 | 10/30 vs Central Dauphin- 4-1 W | |
| 16 | Crestwood High School | Mountain Top, Pennsylvania | 18-2-0 | 17 | 10/27 vs Dallas- 3-0 W, 10/29 vs Wyoming Valley West- 2-1 W OT | |
| 17 | Mechanicsburg High School | Mechanicsburg, Pennsylvania | 14-5-0 | 18 | 10/27 vs ELCO- 7-0 W, 10/30 vs Susquehannock- 5-0 W | |
| 18 | Northern York High School | Dillsburg, Pennsylvania | 19-2-0 | 19 | 10/27 vs East Pennsboro- 3-2 W OT, 10/30 vs Fleetwood- 5-0 W | |
| 19 | Upper Perkiomen High School | Pennsburg, Pennsylvania | 18-1-1 | 20 | 10/26 vs Mount St. Joseph- 4-0 W, 10/18 vs Phoenixville- 8-1 W | |
| 20 | Downingtown West High School | Downingtown, Pennsylvania | 15-4-0 | OC | 10/27 vs Central Bucks East- 3-1 W, 10/29 vs Great Valley- 2-1 W | |
| | | | | | |
| OC | Cumberland Valley High School | Mechanicsburg, Pennsylvania | 15-3-0 | OC | 10/30 vs State College- 3-0 W | |
| OC | Garnet Valley High School | Glen Mills, Pennsylvania | 16-3-0 | OC | 10/27 vs Central Bucks South- 2-0 W, 10/29 vs Souderton- 3-1 W | |
| OC | Great Valley High School | Malvern, Pennsylvania | 17-3-0 | OC | 10/27 vs WC Henderson- 6-1 W, 10/29 vs Downingtown West- 1-2 L | |
| OC | Kennett High School | Kennett Square, Pennsylvania | 15-3-2 | OC | 10/27 vs Boyertown- 3-2 W, 10/29 vs Conestoga- 0-3 L | |
| OC | Merion Mercy Academy | Merion Station, Pennsylvania | 15-4-0 | OC | 10/26 vs Oxford- 9-0 W, 10/28 vs Radnor- 3-2 W | |
| OC | Radnor High School | Radnor, Pennsylvania | 13-4-1 | OC | 10/26 vs Upper Merion- 9-2 W, 10/28 vs Merion Mercy- 2-3 L | |
| OC | Souderton Area High School | Souderton, Pennsylvania | 18-2-0 | 16 | 10/27 vs Neshaminy- 4-1 W, 10/29 vs Garnet Valley- 1-3 L | |
| OC | Southern Lehigh High School | Center Valley, Pennsylvania | 17-0-0 | OC | None | |
2021 PENNSYLVANIA REGION HIGH SCHOOL
