| 1 | Emmaus High School | Emmaus, Pennsylvania | 21-0-0 | 1 | 10/19 vs Parkland- 2-0 W, 10/22 vs Easton- 2-1 W. EPC Champions | |
| 2 | Frank W. Cox High School | Virginia Beach, Virginia | 12-0-0 | 2 | 10/19 vs Tallwood- 10-0 W, 10/21 vs Green Run- 15-0 W | |
| 3 | Episcopal Academy | Newtown Square, Pennsylvania | 14-1-0 | 4 | 10/22 vs Archbishop Carroll- 6-0 W | |
| 4 | The Hill School | Pottstown, Pennsylvania | 13-1-0 | 5 | 10/20 vs Wyoming Seminary- 3-1 W, 10/23 vs Blair Academy- 9-0 W | |
| 5 | Lower Dauphin High School | Hummelstown, Pennsylvania | 17-0-1 | 8 | None | |
| 6 | Villa Maria Academy | Malvern, Pennsylvania | 14-2-1 | 3 | 10/19 @Academy of Notre Dame- 0-1 L, 10/21 vs Archbishop Carroll- 4-0 W | |
| 7 | Wyoming Seminary | Kingston, Pennsylvania | 15-2-0 | 6 | 10/18 vs Lackawanna Trail- 8-3 W, 10/20 vs The Hill School- 1-3 L | |
| 8 | Eastern Regional High School | Voorhees, New Jersey | 17-2-0 | 7 | 10/20 @Oak Knoll- 5-1 W, 10/22 @Lenape- 5-0 W | |
| 9 | Delmar High School | Delmar, Delaware | 12-0-0 | 9 | 10/21 vs Smyrna- 6-1 W | |
| 10 | Palmyra Area High School | Palmyra, Pennsylvania | 14-1-1 | 10 | None | |
| 11 | Kinkaid School | Houston, Texas | 12-1-0 | 12 | 10/21 vs Houston Christian- 11-0 W | |
| 12 | Norfolk Academy | Norfolk, Virginia | 13-2-0 | 15 | 10/19 vs The Steward School- 11-0 W, 10/21 @Catholic- 9-0 W, 10/22 @St. Catherine's School- 10-1 W | |
| 13 | Oak Knoll School | Summit, New Jersey | 16-2-0 | 11 | 10/20 vs Eastern Regional- 1-5 L, 10/23 vs Kent Place- 7-2 W | |
| 14 | Conestoga High School | Berwyn, Pennsylvania | 17-1-0 | 16 | 10/18 @Haverford- 1-0 W, 10/19 vs Harriton- 7-0 W | |
| 15 | West Essex Regional High School | Caldwell, New Jersey | 17-2-0 | 13 | 10/19 @Union- 8-0 W, 10/21 @Bridgewater-Raritan- 10-2 W, 10/23 vs Montclair- 6-0 W | |
| 16 | Camden Catholic High School | Cherry Hill, New Jersey | 18-2-0 | 14 | 10/18 vs Cherry Hill East- 6-0 W, 10/20 vs Cherokee- 1-0 W, 10/23 vs Paul VI- 4-0 W | |
| 17 | Gwynedd Mercy Academy High School | Gwynedd Valley, Pennsylvania | 12-2-1 | 18 | 10/19 @Unionville- 4-1 W | |
| 18 | Kingsway Regional High School | Woolwich Township, New Jersey | 16-1-0 | 17 | 10/18 vs Clearview- 6-0 W, 10/20 vs Woodstown- 6-0 W, 10/21 vs Bishop Eustace- 3-1 W | |
| 19 | Sacred Heart Academy | Louisville, Kentucky | 24-3-0 | 19 | 10/18 vs Eastern- 9-0 W, 10/19 @CAL- 3-1 W, 10/21 vs North Oldham- 1-0 W, 10/23 vs duPont Manual- 2-0 W | |
| 20 | Twin Valley High School | Elverson, Pennsylvania | 19-2-0 | 25 | 10/20 vs Wilson- 2-1 W, 10/23 @Oley Valley- 4-1 W | |
| 21 | Assumption High School | Louisville, Kentucky | 21-5-2 | 21 | 10/18 vs Collegiate- 8-0 W, 10/19 @Male- 7-0 W, 10/21 vs Holy Cross- 10-0 W, 10/23 @CAL- 2-1 W | |
| 22 | Pioneer High School | Pioneer, Michigan | 20-0-0 | 22 | 10/19 vs University Liggett- 8-0 W | |
| 23 | Northport High School | Northport, New York | 16-0-0 | 24 | 10/18 @West Babylon- 9-3 W | |
| 24 | Wyoming Area High School | Exeter, Pennsylvania | 15-1-0 | NR | 10/18 vs Lake Lehman- 1-0 W, 10/21 vs Hazleton Area- 2-0 W | |
| 25 | Walpole High School | Walpole, Massachusetts | 14-0-0 | NR | 10/18 vs Newton North- 1-0 W, 10/20 @Milton- 4-0 W, 10/22 vs Westwood- 2-0 W | |
2021 HIGH SCHOOL WEEK #7
