| 1 | Walpole High School | Walpole, Massachusetts | 11-0-0 | 1 | 10/11 @Franklin- 1-0 W, 10/13 vs Needham- 1-0 W | |
| 2 | Phillips Academy Andover | Andover, Massachusetts | 9-0-0 | 2 | 10/13 vs Milton- 4-2 W, 10/16 @St Paul's- 4-0 W | |
| 3 | Masconomet Regional High School | Boxford, Massachusetts | 12-0-1 | 3 | 10/12 vs Manchester Essex- 5-0 W, 10/13 vs Beverly- 3-0 W, 10/15 @Marblehead- 4-0 W | |
| 4 | Andover High School | Andover, Massachusetts | 12-0-1 | 4 | 10/11 vs Needham- 1-0 W, 10/13 @Lowell- 6-0 W, 10/15 vs Chelmsford- 4-1 W | |
| 5 | Watertown High School | Watertown, Massachusetts | 12-0-0 | 5 | 10/11 vs Reading- 1-0 W, 10/14 @Wakefield- 6-0 W | |
| 6 | Skowhegan Area High School | Skowhegan, Maine | 13-0-0 | 6 | 10/11 vs Brewer- 7-0 W, 10/13 @Messalonskee- 4-1 W, 10/15 vs Mt Blue- 5-0 W | |
| 7 | Franklin High School | Franklin, Massachusetts | 13-1-0 | 15 | 10/11 vs Walpole- 0-1 L, 10/12 @Sharon- 7-0 W, 10/14 vs Attleboro- 8-1 W | |
| 8 | Tabor Academy | Marion, Massachusetts | 7-3-0 | 14 | 10/13 vs Lawrence- 9-1 W, 10/16 @Greenwich Academy- 0-1 L | |
| 9 | Cheverus High School | Portland, Maine | 14-0-0 | 10 | 10/11 @ Portland/Deering- 11-0 W, 10/13 @Westbrook- 11-1 W, 10/14 @Massabesic- 3-2 W | |
| 10 | Wellesley High School | Wellesley, Massachusetts | 10-1-1 | NR | 10/13 @Newton North- 4-3 W, 10/15 vs Concord-Carlisle- 5-4 W | |
| 11 | Brooks School | North Andover, Massachusetts | 6-1-1 | 16 | 10/15 @Rivers School- 2-1 W | |
| 12 | Winchester High School | Winchester, Massachusetts | 10-1-2 | NR | 10/11 @Wakefield- 3-0 W, 10/12 vs Lincoln-Sudbury- 2-1 W, 10/14 @Reading- 1-0 W | |
| 13 | Exeter High School | Exeter, New Hampshire | 15-1-0 | 8 | 10/12 @Windham- 0-1 L, 10/14 vs Nashua South- 5-0 W | |
| 14 | Concord-Carlisle High School | Concord, Massachusetts | 10-1-1 | 9 | 10/13 vs Wayland- 5-1 W, 10/15 @Wellesley- 4-5 L | |
| 15 | Bedford High School | Bedford, New Hampshire | 15-1-0 | 13 | 10/12 @Manchester Central-West- 2-1 W, 10/13 vs Dover- 3-2 W | |
| 16 | Middlesex School | Concord, Massachusetts | 8-2-0 | 17 | 10/13 @Governor's Academy- 2-1 W OT, 10/15 @Groton School- 5-2 W | |
| 17 | Sandwich High School | East Sandwich, Massachusetts | 10-1-1 | 11 | 10/13 vs Dennis Yarmouth- 3-0 W, 10/15 vs Falmouth- 0-1 L | |
| 18 | Wachusett Regional High School | Holden, Massachusetts | 10-0-4 | 18 | 10/11 vs Nipmuc- 3-0 W | |
| 19 | Noble & Greenough School | Dedham, Massachusetts | 7-1-0 | OC | 10/13 vs St. Mark's- 4-1 W, 10/16 vs Thayer Academy- 3-1 W | |
| 20 | Westwood High School | Westwood, Massachusetts | 9-0-1 | OC | 10/13 @Bellingham- 6-0 W, 10/14 @Weston- 4-1 W | |
| | | | | | |
| OC | Bellows Falls Union High School | Westminster, Vermont | 12-0-0 | 19 | 10/12 vs Hartford- 2-1 W, 10/14 @Woodstock- 3-1 W | |
| OC | Falmouth High School | Falmouth, Massachusetts | 8-1-4 | NR | 10/11 @Barnstable- 2-2 T, 10/13 vs Barnstable- 1-1 T, 10/15 @Sandwich- 1-0 W | |
| OC | Holliston High School | Holliston, Massachusetts | 8-1-2 | NR | 10/13 @Dover-Sherborn- 3-0 W | |
| OC | Longmeadow High School | Longmeadow, Massachusetts | 12-1-1 | 7 | 10/11 @South Hadley- 6-0 W, 10/13 vs Minnechaug Regional- 0-1 L, 10/15 @West Springfield- 3-0 W | |
| OC | Nashoba Regional High School | Bolton, Massachusetts | 10-2-1 | OC | 10/12 vs Westborough- 6-0 W, 10/13 @Marlborough- 2-0 W | |
| OC | Scarborough High School | Scarborough, Maine | 13-1-0 | 20 | 10/12 vs Marshwood- 5-0 W, 10/14 @South Portland- 9-0 W | |
| OC | South Burlington High School | South Burlington, Vermont | 12-0-0 | NR | 10/13 vs Colchester- 2-0 W, 10/15 vs Rice Memorial- 2-1 W | |
| OC | The Rivers School | Weston, Massachusetts | 6-2-1 | OC | 10/13 @BB&N- 4-0 W, 10/15 vs Brooks- 1-2 L | |
| OC | Windham High School | Windham, New Hampshire | 13-2-1 | OC | 10/12 vs Exeter- 1-0 W, 10/14 @Londonderry- 4-1 W | |
2021 NEW ENGLAND REGION HIGH SCHOOL
