| 1 | Kinkaid School | Houston, Texas | 9-1-0 | 1 | 10/5 vs Duchesne Academy of the Sacred Heart- 11-0 W | |
| 2 | Sacred Heart Academy | Louisville, Kentucky | 18-3-0 | 2 | 10/5 vs Ballard- 2-0 W, 10/8 vs Eastern Regional (NJ)- 1-8 L, 10/9 @Wyoming Seminary (PA)- 2-3 L, 10/9 @Lake Lehman (PA)- 1-0 W | |
| 3 | Assumption High School | Louisville, Kentucky | 16-5-2 | 3 | 10/4 vs Highlands Latin- 9-0 W, 10/8 @Norfolk Academy (VA)- 1-2 L OT, 10/9 @First Colonial (VA)- 2-3 L, 10/9 @Frank W Cox (VA)- 1-2 L | |
| 4 | Ann Arbor Pioneer High School | Pioneer, Michigan | 17-0-0 | 4 | 10/4 vs Huron- 5-0 W, 10/6 @Dexter- 7-1 W, 10/8 vs Thomas Worthington (OH)- 5-0 W | |
| 5 | Villa Duchesne & Oak Hill School | Frontenac, Missouri | 16-1-2 | 5 | 10/5 vs Marquette- 6-0 W, 10/7 @Whitfield- 8-1 W | |
| 6 | St. John's School | Houston, Texas | 8-2-0 | 6 | 10/7 vs Episcopal- 5-0 W | |
| 7 | Scripps Ranch High School | San Diego, California | 11-0-1 | 8 | 10/9 vs Archbishop Mitty- 2-1 W | |
| 8 | New Trier High School | Winnetka, Illinois | 17-6-0 | 10 | 10/5 vs NSCD- 2-0 W, 10/8 @Glenbard West- 3-0 W, 10/9 vs DSHA- 5-0 W | |
| 9 | Lake Forest High School | Lake Forest, Illinois | 17-3-0 | 13 | 10/4 vs Glenbard West- 3-0 W | |
| 10 | Canyon Hills High School | Sain Diego, California | 13-2-0 | 14 | 10/5 vs Rancho Buena Vista- 5-0 W, 10/7 vs Archbishop Mitty- 2-0 W | |
| 11 | Thomas Worthington High School | Worthington, Ohio | 12-1-1 | 7 | 10/4 vs Worthington Kilbourne- 5-0 W, 10/6 vs Olentangy Liberty- 2-0 W, 10/8 vs Pioneer (MI)- 0-5 L | |
| 12 | Ballard High School | Louisville, Kentucky | 12-7-0 | 16 | 10/5 @Sacred Heart Academy- 0-2 L | |
| 13 | Bishop Watterson High School | Columbus, Ohio | 9-1-1 | 15 | 10/5 vs Columbus Academy- 2-1 W | |
| 14 | Skyline High School | Ann Arbor, Michigan | 9-2-1 | 17 | 10/6 @Saline-1-1 T | |
| 15 | Glenbrook South High School | Glenview, Illinois | 14-2-0 | NR | 10/4 @Lakes- 10-2 W, 10/6 vs OPRF- 3-0 W, 10/9 vs Saint Ignatius College Prep- 9-1 W | |
| 16 | New Albany High School | New Albany, Ohio | 11-1-1 | 11 | 10/4 @Granville- 1-0 W | |
| 17 | Harvard-Westlake School | Los Angeles, California | 10-1-0 | 18 | 10/5 @Chaminade- 2-1 W, 10/7 vs Chaminade-6-0 W | |
| 18 | Saline High School | Saline, Michigan | 8-3-1 | OC | 10/6 vs Skyline- 1-1 T | |
| 19 | Torrey Pines High School | San Diego, California | 12-3-0 | OC | 10/6 @Canyon Crest Academy-2-1 W | |
| 20 | Archbishop Mitty High School | San Jose, California | 6-3-2 | NR | 10/5 vs Los Gatos- 1-0 W | |
| | | | | | |
| OC | Canyon Crest Academy | San Diego, California | 11-5-0 | OC | 10/6 vs Torrey Pines- 1-2 L, 10/8 vs Westview- 10-0 W | |
| OC | Christopher High School | Gilroy, California | 10-1-1 | OC | 10/4 @San Benito- 4-1 W, 10/6 @Carmel- 4-0 W | |
| OC | Columbus Academy | Columbus, Ohio | 10-3-1 | 12 | 10/5 vs Bishop Watterson- 1-2 L, 10/8 vs Shaker Heights- 1-2 L, 10/9 vs Hudson- 3-2 W OT | |
| OC | Los Gatos High School | Los Gatos, California | 7-1-0 | 9 | 10/5 @Archbishop Mitty- 0-1 L, 10/7 vs Los Altos- 4-0 W | |
| OC | MICDS | Saint Louis, Missouri | 11-3-0 | OC | 10/4 vs Marquette- 5-0 W, 10/6 vs Summit- 6-1 W, 10/8 vs Visitation- 6-3 W | |
| OC | Oak Park & River Forest High School | Oak Park, Illinois | 14-5-1 | 20 | 10/4 vs Francis Parker- 1-0 W, 10/6 @Glenbrook South- 0-3 L, 10/7 vs Homewood Flossmoor- 7-0 W | |
| OC | Olentangy Liberty High School | Powell, Ohio | 8-1-1 | 19 | 10/6 vs Thomas Worthington- 0-2 L | |
| OC | Saint Francis High School | Mountain View, California | 9-1-0 | OC | 10/7 vs St Ignatius- 2-0 W | |
2021 WEST/MID-WEST REGION HIGH SCHOOL
