| 1 | Kinkaid School | Houston, Texas | 8-1-0 | 1 | 9/30 @Episcopal- 9-0 W | |
| 2 | Sacred Heart Academy | Louisville, Kentucky | 16-1-0 | 2 | 9/30 vs CAL- 5-3 W | |
| 3 | Assumption High School | Louisville, Kentucky | 15-2-2 | 3 | 9/28 vs duPont Manual- 6-0 W, 9/29 @Male- 1-0 W, 9/30 @Louisville Collegiate- 8-1 W | |
| 4 | Pioneer High School | Pioneer, Michigan | 14-0-0 | 4 | 9/29 vs Saline- 4-2 W | |
| 5 | Villa Duchesne & Oak Hill School | Frontenac, Missouri | 14-1-2 | 5 | 9/28 @Visitation- 4-0 W, 9/30 vs Summit- 8-0 W, 10/2 @St Joseph- 5-0 W | |
| 6 | St. John's School | Houston, Texas | 7-2-0 | 6 | 9/30 vs Houston Christian- 12-0 W | |
| 7 | Thomas Worthington High School | Worthington, Ohio | 10-0-1 | 8 | 9/29 vs Columbus Academy- 2-0 W | |
| 8 | Scripps Ranch High School | San Diego, California | 10-0-1 | 9 | None | |
| 9 | Los Gatos High School | Los Gatos, California | 6-0-0 | 12 | 9/28 vs St. Ignatius- 6-0 W, 9/20 @Saint Francis- 2-1 W OT | |
| 10 | New Trier High School | Winnetka, Illinois | 14-6-0 | 7 | 9/30 vs OPRF- 0-1 L, 10/1 vs Loyola- 3-0 W | |
| 11 | New Albany High School | New Albany, Ohio | 10-1-1 | 10 | 9/28 vs Worthington Kilbourne- 6-0 W | |
| 12 | Columbus Academy | Columbus, Ohio | 8-2-1 | 11 | 9/29 vs Thomas Worthington- 0-2 L | |
| 13 | Lake Forest High School | Lake Forest, Illinois | 16-3-0 | 13 | 9/29 @Francis W Parker- 3-1 W | |
| 14 | Canyon Hills High School | Sain Diego, California | 11-2-0 | 14 | 9/29 @Torrey Pines- 2-0 W | |
| 15 | Bishop Watterson High School | Columbus, Ohio | 8-1-1 | 15 | 10/2 vs Mount Notre Dame- 5-1 W | |
| 16 | Ballard High School | Louisville, Kentucky | 12-6-0 | 16 | None | |
| 17 | Skyline High School | Ann Arbor, Michigan | 9-2-0 | 17 | 10/2 vs East Grand Rapids- W | |
| 18 | Harvard-Westlake School | Los Angeles, California | 8-1-0 | 18 | 10/1 @Edison- 6-0 W, 10/2 @Marina- 9-0 W | |
| 19 | Olentangy Liberty High School | Powell, Ohio | 8-0-1 | 19 | None | |
| 20 | Oak Park & River Forest High School | Oak Park, Illinois | 12-4-1 | NR | 9/28 @Evanston Twp- 2-0 W, 9/30 vs New Trier- 1-0 W | |
| | | | | | |
| OC | Canyon Crest Academy | San Diego, California | 10-4-0 | OC | 9/28 vs University City- 8-0 W, 9/30 vs Cathedral Catholic- 8-2 W | |
| OC | Christopher High School | Gilroy, California | 8-1-1 | OC | 9/29 @Notre Dame- 10-0 W, 10/1 vs Stevenson- 9-0 W | |
| OC | MICDS | Saint Louis, Missouri | 8-3-0 | OC | 9/29 @Cor Jesu- 2-1 W | |
| OC | North Oldham High School | Goshen, Kentucky | 14-4-0 | OC | 9/28 vs Eastern 6-0 W, 9/30 vs KCD- 3-1 W | |
| OC | Saint Francis High School | Mountain View, California | 8-1-0 | OC | 9/28 @Presentation- 7-0 W, 9/30 vs Los Gatos- 1-2 L | |
| OC | Saline High School | Saline, Michigan | 8-3-0 | OC | 9/29 @Pioneer- 2-4 L | |
| OC | Torrey Pines High School | San Diego, California | 11-3-0 | 20 | 9/29 vs Canyon Hills- 0-2 L | |
2021 WEST/MID-WEST REGION HIGH SCHOOL
