| 1 | Phillips Academy Andover | Andover, Massachusetts | 18-0-1 | NEPSAC A Champions |
| 2 | Andover High School | Andover, Massachusetts | 21-0-1 | MIAA Division I State Champions |
| 3 | Walpole High School | Walpole, Massachusetts | 21-1-0 | MIAA Division I State Runner-Up |
| 4 | Watertown High School | Watertown, Massachusetts | 23-0-0 | MIAA Division 3 State Champions |
| 5 | Cheverus High School | Portland, Maine | 19-0-0 | Maine Class A State Champions |
| 6 | Masconomet Regional High School | Boxford, Massachusetts | 19-1-1 | MIAA Division 2 State Semifinalist |
| 7 | Concord-Carlisle High School | Concord, Massachusetts | 16-2-1 | Division I State Semifinalist |
| 8 | Exeter High School | Exeter, New Hampshire | 18-1-0 | NHIAA Division I State Champions |
| 9 | Skowhegan Area High School | Skowhegan, Maine | 17-1-0 | Maine Class A State Finalist |
| 10 | Tabor Academy | Marion, Massachusetts | 15-4-0 | NEPSAC A Quarterfinalist |
| 11 | Franklin High School | Franklin, Massachusetts | 21-2-0 | Division I State Semifinalist |
| 12 | Brooks School | North Andover, Massachusetts | 15-3-1 | NEPSAC B Champions |
| 13 | Wellesley High School | Wellesley, Massachusetts | 15-3-1 | Division I State Quarterfinalist |
| 14 | Westwood High School | Westwood, Massachusetts | 16-1-1 | MIAA Division 2 State Champions |
| 15 | Middlesex School | Concord, Massachusetts | 16-4-1 | NEPSAC B Runner-Up |
| 16 | Windham High School | Windham, New Hampshire | 15-3-1 | NHIAA Division State Runner-Up |
| 17 | Winchester High School | Winchester, Massachusetts | 16-2-2 | Division I State Quarterfinalist |
| 18 | Scarborough High School | Scarborough, Maine | 16-2-0 | Maine Class A Regional Finalist |
| 19 | Nashoba Regional High School | Bolton, Massachusetts | 17-3-2 | MIAA Division 2 State Runner-Up |
| 20 | Sandwich High School | East Sandwich, Massachusetts | 18-2-2 | MIAA Division 3 State Runner-Up |
| | | | |
| OC | Bedford High School | Bedford, New Hampshire | 16-2-0 | NHIAA Division I State Semifinalist |
| OC | Bellows Falls Union High School | Westminster, Vermont | 16-1-0 | Vermont Division 1 State Finalist |
| OC | Falmouth High School | Falmouth, Massachusetts | 15-2-4 | MIAA Division 2 State Semifinalist |
| OC | Longmeadow High School | Longmeadow, Massachusetts | 18-3-1 | Division 2 State Quaterfinalist |
| OC | Noble & Greenough School | Dedham, Massachusetts | 11-4-0 | |
| OC | Shrewsbury High School | Shrewsbury, Massachusetts | 13-4-4 | Division I State Quarterfinalist |
| OC | South Burlington High School | South Burlington, Vermont | 16-0-1 | Vermont Division 1 State Champions |
| OC | The Rivers School | Weston, Massachusetts | 13-4-1 | NEPSAC B Semifinalist |
| OC | Wachusett Regional High School | Holden, Massachusetts | 13-2-4 | Division I State Quarterfinalist |
2021 NEW ENGLAND REGION HIGH SCHOOL
