| 1 | Hershey | Hershey, PA | 19-5-1 | 6 | Bri Price | PIAA AAA State Champions, District III AAA Semifinalist (lost to Lower Dauphin 0-1), 4th Place through Playback |
| 2 | Donegal | Mount Joy, PA | 28-1-0 | 3 | Jessica Shellenberger | PIAA AA State Champions, District III AA Champions |
| 3 | Lower Dauphin | Hummelstown, PA | 22-2-1 | 4 | Linda Kreiser | PIAA AAA State Runner-Up (lost to Hershey 1-2 OT), District III AAA Champions |
| 4 | Wyoming Seminary | Kingston, PA | 21-2-1 | 7 | Karen Klassner | PIAA A State Champions, District II A Champions |
| 5 | Episcopal Academy | Newtown Square, PA | 15-2-2 | 8 | Gina Buggy | PAISAA Champions |
| 6 | Emmaus | Emmaus, PA | 26-1-0 | 1 | Sue Butz-Stavin | PIAA AAA State Semifinalist (lost to Hershey 3-5), EPC Champions, District XI AAA Champions |
| 7 | Palmyra Area | Palmyra, PA | 19-6-1 | 13 | Kent Harshman | PIAA AA State Runner-Up (lost to Donegal 0-1 OT), District III AA Runner-Up (lost to Donegal 0-3) |
| 8 | Penn Manor | Millersville, PA | 22-3-1 | 2 | Matt Soto | PIAA AAA State Quarterfinalist (lost to Hershey 0-1), District III AAA Runner-Up (lost to Lower Dauphin 0-2) |
| 9 | Wilson | West Lawn, PA | 22-4-0 | 11 | Kim Underwood | PIAA AAA State Semifinalist (lost to Lower Dauphin 0-1), District III AAA Semifinalist (lost to Penn Manor 1-2), 3rd Place through Playback |
| 10 | Germantown Academy | Fort Washington, PA | 15-5-1 | 20 | Jackie Connard | PAISAA Runner-Up (lost to Episcopal Academy 3-4 OT SO), Inter-AC Champions |
| 11 | Academy of Notre Dame de Namur | Villanova, PA | 18-3-1 | 9 | Adele Williams | PAISAA Semifinalist (lost to Episcopal Academy 0-1) |
| 12 | Villa Maria Academy | Malvern, PA | 19-3-0 | 10 | Katie Evans | PIAA AA State Quarterfinalist (lost to Palmyra 1-2 OT), District I AA Champions |
| 13 | Greenwood | Millerstown, PA | 21-2-0 | 12 | Kent Houser | PIAA A State Semifinalist (lost to Wyoming Seminary 0-4), District III A Champions |
| 14 | Newport | Newport, PA | 18-7-1 | NR | Cheryl Capozzoli | PIAA A State Runner-Up (lost to Wyoming Seminary 0-2), District III A Quarterfinalist (lost to Greenwood 0-4)- 3rd Place through Playback |
| 15 | Oley Valley | Oley, PA | 25-3-0 | 5 | Tiffany Cappellano | PIAA A State Semifinalist (lost to Newport 1-3), District III A Runner-Up (lost to Greenwood 1-2 OT), BCIAA Champions |
| 16 | Owen J. Roberts | Pottstown, PA | 22-3-0 | 15 | Amy Hoffman | PIAA AAA State First Round (lost to Hershey 1-2 OT), District I AAA Champions |
| 17 | Central Bucks East | Doylestown, PA | 20-3-0 | 14 | Meghann Spratt | PIAA AAA State Quarterfinalist (lost to Emmaus 1-2 OT), District I AAA Semifinalist (lost to Owen J. Roberts 0-2) |
| 18 | Wyoming Valley West | Plymouth, PA | 16-4-1 | OC | Linda Fithian | PIAA 2A State Semifinalist (lost to Palmyra 1-3), District II AA Champions |
| 19 | Wyoming Area | Exeter, PA | 18-3-2 | OC | Erin McGinley | PIAA A Quarterfinalist (lost to Newpor 1-2 OT), District II A Runner-Up (lost to Wyoming Seminary 2-3) |
| 20 | Mount Saint Joseph Academy | Flourtown, PA | 17-6-1 | 16 | Sue Wentzel | PIAA AA State First Round (lost to Palmyra 0-1), District I AA Semifinalist (lost to Villa Maria Academy 0-1) |
| | | | | | |
| OC | Archbishop Carroll | Radnor, PA | 18-5-0 | NR | Christina Elisio | PIAA AA Quarterfinalist (lost to Donegal 0-3), District XII Champions, Catholic League Champions |
| OC | Bangor Area | Bangor, PA | 21-2-1 | NR | Lisa Kienzle | PIAA AA State Quarterfinalist (lost to Wyoming Valley West 0-1), District XI AA Champions, Colonial League Champions |
| OC | Central Dauphin | Harrisburg, PA | 13-6-0 | OC | Janelle Burger | District III AAA Quarterfinalist (lost to Wilson 1-2) |
| OC | Downingtown West | Downingtown, PA | 17-6-0 | OC | Steph Bullock | PIAA AAA State First Round (lost to Emmaus 0-1), District I AAA Quarterfinalist-5th Place through Playback |
| OC | Easton Area | Easton, PA | 19-5-0 | 18 | Casey Eck | PIAA AAA State First Round (lost to Perkiomen Valley 2-3), District XI Runner-up (lost to Emmaus 0-1) |
| OC | Exeter Township | Reading, PA | 20-3-0 | OC | Lisa McCoy | District III AAA Quarterfinalist (lost to Hershey 0-4) |
| OC | Methacton | Eagleville, PA | 18-8-0 | 17 | Morgan Briggs | PIAA AAA State Quarterfinalist (lost to Lower Dauphin 0-3), District I AAA Semifinalist (lost to Perkiomen Valley 2-3)- 3rd Place through Playback |
| OC | Perkiomen Valley | Collegeville, PA | 23-3-0 | OC | Erik Enters | PIAA AAA State Quarterfinalist (lost to Wilson 1-5), District I AAA Runner-Up (lost to Owen J. Roberts 0-2) |
| OC | Selinsgrove Area | Selinsgrove, PA | 16-3-2 | OC | Roz Erb | PIAA AA State Quarterfinalist (lost to Twin Valley 1-4), District IV AA Champions |
| OC | Souderton | Souderton, PA | 16-5-0 | OC | Susan Casiato | PIAA AAA State First Round (lost to Lower Dauphin 0-2), District I AAA Quarterfinalist- 6th Place through Playback |
| OC | The Hill School | Pottstown, PA | 14-4-1 | OC | Jen Weissbach | MAPL Champions, PAISAA Semifinalist (lost to Germantown Academy 1-3) |
| OC | Twin Valley | Elverson, PA | 15-11-0 | NR | Kim Walsh | PIAA 2A State Semifinalist (lost to Donegal 0-2), District III AA Semifinalist (lost to Donegal 1-6), 3rd Place finish through Playback |
2018 PENNSYLVANIA REGION HIGH SCHOOL
